{"id":98,"date":"2020-05-26T17:52:42","date_gmt":"2020-05-26T08:52:42","guid":{"rendered":"https:\/\/gucvmed.med.gunma-u.ac.jp\/0_web\/?page_id=98"},"modified":"2024-09-13T08:51:25","modified_gmt":"2024-09-12T23:51:25","slug":"%e5%b0%8f%e6%9d%bf%e6%a9%8b%e3%82%b0%e3%83%ab%e3%83%bc%e3%83%97","status":"publish","type":"page","link":"https:\/\/gucvmed.med.gunma-u.ac.jp\/?page_id=98","title":{"rendered":"\u5c0f\u677f\u6a4b\u30b0\u30eb\u30fc\u30d7"},"content":{"rendered":"
\n

\u5fc3\u80a5\u5927\u3068\u5fc3\u4e0d\u5168<\/h4>\n

\u4eba\u9593\u306e\u5fc3\u81d3\u306f250-300g\u306e\u7b4b\u8089\u3067\u3067\u304d\u305f\u888b\u3067\u3059\u304c\u300170\u5e74\u751f\u304d\u305f\u3068\u3057\u306630\u5104\u56de\u53ce\u7e2e\u3057\u30012\u5104L\u306e\u8840\u6db2\u3092\u62cd\u51fa\u3057\u3066\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u304c\u6301\u3063\u3066\u3044\u308b\u7b4b\u8089\u306e\u306a\u304b\u3067\u6700\u3082\u9177\u4f7f\u3055\u308c\u3066\u3044\u308b\u7b4b\u8089\u3067\u3059\u3002\u975e\u5e38\u306b\u9811\u4e08\u306a\u81d3\u5668\u3067\u3042\u308b\u3079\u304d\u5fc3\u81d3\u3067\u3059\u304c\u3001\u8840\u5727\u304c\u9ad8\u304b\u3063\u305f\u308a\u3001\u5fc3\u7b4b\u6897\u585e\u3092\u8d77\u3053\u3057\u305f\u308a\u3001\u907a\u4f1d\u5b50\u304c\u5c11\u3057\u7570\u5e38\u3092\u6765\u3057\u305f\u308a\u3059\u308b\u3068\u3001\u5fc3\u81d3\u80a5\u5927\u304b\u3089\u53ce\u7e2e\u4e0d\u5168\u3092\u8d77\u3053\u3057\u3001\u30dd\u30f3\u30d7\u5931\u8abf\uff1d\u5fc3\u4e0d\u5168\u306b\u9665\u308a\u307e\u3059\u3002\u5fc3\u81d3\u306f\u5916\u7684\u30b9\u30c8\u30ec\u30b9\u306b\u5bfe\u3057\u3066\u3001\u4ee3\u511f\u7684\u306b\u80a5\u5927\u3092\u8d77\u3053\u3057\u3001\u305d\u306e\u6a5f\u80fd\u3092\u88dc\u304a\u3046\u3068\u3057\u307e\u3059\u304c\u3001\u9577\u671f\u9593\u30b9\u30c8\u30ec\u30b9\u306b\u3055\u3089\u3055\u308c\u308b\u3068\u3001\u305d\u306e\u4ee3\u511f\u6a5f\u8ee2\u304c\u7834\u305f\u3093\u3057\u305f\u308a\u3001\u4ee3\u511f\u6a5f\u8ee2\u305d\u306e\u3082\u306e\u304c\u5fc3\u81d3\u306b\u3068\u3063\u3066\u5897\u60aa\u56e0\u5b50\u3068\u3057\u3066\u50cd\u3044\u305f\u308a\u3057\u307e\u3059\u3002
\n\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u95a2\u3057\u3066\u306f\u3001\u3053\u306e30\u5e74\u9593\u3067\u6570\u591a\u304f\u306e\u7814\u7a76\u304c\u306a\u3055\u308c\u3066\u3001\u591a\u304f\u306e\u3053\u3068\u304c\u5206\u304b\u3063\u3066\u304d\u307e\u3057\u305f\u3002\u3057\u304b\u3057\u5fc3\u4e0d\u5168\u3067\u4ea1\u304f\u306a\u308b\u4eba\u306f\u591a\u304f\u3001\u307e\u305f\u5fc3\u79fb\u690d\u3092\u5f85\u3063\u3066\u3044\u308b\u91cd\u75c7\u306e\u5fc3\u4e0d\u5168\u306e\u4eba\u306f\u4e16\u754c\u4e2d\u306b\u305f\u304f\u3055\u3093\u3044\u307e\u3059\u3002\u3057\u304b\u3057\u5fc3\u4e0d\u5168\u306e\u85ac\u7269\u6cbb\u7642\u306fACE\u963b\u5bb3\u85ac\u3068\u03b2\u906e\u65ad\u85ac\u304c\u3042\u308b\u3060\u3051\u3067\u305d\u3053\u304b\u3089\u5927\u304d\u306a\u9032\u6b69\u304c\u306a\u3044\u3068\u8a00\u3063\u3066\u3082\u904e\u8a00\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3093\u306a\u4e2d\u3001SGLT2\u963b\u5bb3\u85ac\u3084ARNI\u3068\u3044\u3063\u305f\u65b0\u305f\u306a\u53ef\u80fd\u6027\u3092\u3082\u3064\u6cbb\u7642\u85ac\u304c\u51fa\u73fe\u3057\u3001\u5fc3\u4e0d\u5168\u6cbb\u7642\u304c\u5909\u308f\u308a\u3064\u3064\u3042\u308a\u307e\u3059\u3002
\n\u308f\u305f\u304f\u3057\u5c0f\u677f\u6a4b\u306f\u7fa4\u99ac\u5927\u5b66\u3067\u7814\u7a76\u306e\u57fa\u790e\u3092\u5b66\u3093\u3060\u3042\u3068\u3001\u30a2\u30e1\u30ea\u30ab\u306eJohns Hopkins\u5927\u5b66\u3001David A. Kass\u6559\u6388\u306e\u4e0b\u3067\u3001\u5fc3\u81d3\u751f\u7406\u5b66\u3068\u30de\u30a6\u30b9\u306e\u75c5\u614b\u30e2\u30c7\u30eb\u3092\u5b66\u3073\u30012011\u5e74\u306b\u5e30\u56fd\u3002\u5206\u5b50\u3068\u751f\u7406\u5b66\u3068\u3092\u3064\u306a\u3052\u308b\u3088\u3046\u306a\u7814\u7a76\u30b9\u30bf\u30a4\u30eb\u3092\u78ba\u7acb\u3057\u307e\u3057\u305f\u3002
\n\u5c0f\u677f\u6a4b\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u3053\u306e\u5fc3\u80a5\u5927\u3001\u5fc3\u4e0d\u5168\u306e\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u660e\u3089\u304b\u306b\u3057\u3001\u65b0\u305f\u306a\u6cbb\u7642\u6cd5\u3092\u78ba\u7acb\u3059\u308b\u3053\u3068\u3092\u3001\u6700\u7d42\u76ee\u6a19\u306b\u3057\u3066\u3044\u307e\u3059\u3002\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u89e3\u660e\u3059\u308b\u65b9\u6cd5\u3068\u3057\u3066\u3001\u907a\u4f1d\u5b50\u6539\u5909\u30de\u30a6\u30b9\u3092\u7528\u3044\u3001\u3055\u3089\u306b\u305d\u3053\u306b\u5727\u8ca0\u8377\u3001\u5fc3\u7b4b\u6897\u585e\u3001\u6162\u6027\u814e\u4e0d\u5168\u306a\u3069\u306e\u75c5\u7684\u306a\u30b9\u30c8\u30ec\u30b9\u3092\u304b\u3051\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30d2\u30c8\u306e\u75c5\u614b\u306b\u8fd1\u3044\u30e2\u30c7\u30eb\u3092\u4f5c\u308a\u3001\u8a73\u7d30\u306b\u89e3\u6790\u3092\u884c\u3044\u307e\u3059\u3002
\n\u3054\u304f\u6700\u8fd1\u3001\u5171\u540c\u7814\u7a76\u8005\u3068\u7d30\u80de\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\u3067\u3042\u308bATP\u3092\u53ef\u8996\u5316\u3067\u304d\u308b\u30de\u30a6\u30b9\u3092\u958b\u767a\u3002\u3046\u3054\u3044\u3066\u3044\u308b\u5fc3\u81d3\u3067\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u4ee3\u8b1d\u3092\u30e2\u30cb\u30bf\u30fc\u3059\u308b\u6280\u8853\u3092\u958b\u767a\u3057\u307e\u3057\u305f\uff08\u672a\u767a\u8868\uff09\u3002\u4e16\u754c\u30c8\u30c3\u30d7\u30af\u30e9\u30b9\u306e\u6280\u8853\u3092\u7528\u3044\u3066\u3001\u672a\u6765\u306e\u5fc3\u81d3\u75c5\u6cbb\u7642\u958b\u767a\u306b\u5411\u3051\u305f\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u304d\u307e\u3059\u3002<\/p>\n

\"\"<\/p>\n

\u5fc3\u80a5\u5927\u3001\u5fc3\u4e0d\u5168\u306e\u3068\u304d\u306b\u5fc3\u7b4b\u7d30\u80de\u5185\u3067\u8d77\u304d\u3066\u3044\u308b\u7d30\u80de\u5185\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\u306e\u6d3b\u6027\u5316\u3002\u672a\u6765\u306e\u6cbb\u7642\u30bf\u30fc\u30b2\u30c3\u30c8\u3067\u3059\u3002<\/p>\n

\uff08Koitabashi & Kass, Nature Review Cardiology\u3088\u308a\uff09<\/p>\n<\/section>\n

\n

\u30e1\u30f3\u30d0\u30fc<\/h4>\n

\u5c0f\u677f\u6a4b\u7d00\u901a\u3000(\u8b1b\u5e2b)<\/p>\n<\/section>\n

\n

\u7814\u7a76\u30c6\u30fc\u30de<\/h4>\n

1) \u5fc3\u81d3\u306e\u30b9\u30c8\u30ec\u30b9\u5fdc\u7b54\uff5e\u7d30\u80de\u7279\u7570\u7684\u5fdc\u7b54\u304c\u5fc3\u81d3\u5168\u4f53\u306b\u4e0e\u3048\u308b\u5f71\u97ff\uff5e
\n2) \u62cd\u52d5\u3059\u308b\u5fc3\u81d3\u306b\u304a\u3051\u308bATP\u306e\u53ef\u8996\u5316
\n3) \u80ba\u9ad8\u8840\u5727\u75c7\u3068TGF\u03b2\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0
\n4) \u30e1\u30bf\u30dc\u30ea\u30c3\u30af\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3001FGF21\u306e\u5fc3\u80a5\u5927\u30fb\u5fc3\u4e0d\u5168\u306b\u304a\u3051\u308b\u5f79\u5272
\n5) \u30bf\u30a4\u30c1\u30f3\u306e\u30ea\u30f3\u9178\u5316\u3068\u5fc3\u81d3\u62e1\u5f35\u969c\u5bb3
\n\u306a\u3069\u3002<\/p>\n<\/section>\n

\n

\u5b9f\u9a13\u624b\u6280<\/h4>\n

\u30de\u30a6\u30b9\u30e2\u30c7\u30eb<\/h5>\n

1) \u5927\u52d5\u8108\u7e2e\u7a84\u30e2\u30c7\u30eb\u3000TAC
\n2) \u5fc3\u7b4b\u6897\u585e\u30e2\u30c7\u30eb
\n3) \u814e\u4e0d\u5168\u30e2\u30c7\u30eb
\n4) \u80ba\u9ad8\u8840\u5727\u75c7\u30e2\u30c7\u30eb<\/p>\n

\u5fc3\u30a8\u30b3\u30fc<\/h5>\n

\u5fc3\u81d3\u30ab\u30c6\u30fc\u30c6\u30eb\u3000(\u30b3\u30f3\u30c0\u30af\u30bf\u30f3\u30b9\u30ab\u30c6\u30fc\u30c6\u30eb\u6cd5)
\n\u8840\u5727\u6e2c\u5b9a<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\u7d30\u80de\u57f9\u990a<\/h5>\n

1) Neonatal rat cardiac myocytes
\n2) Neonatal rat cardiac fibroblasts
\n3) Adult rat cardiac myocytes
\n4) Adult rat cardiac fibroblasts
\n5) Adult mouse cardiac myocytes
\n6) Adult mouse cardiac fibroblasts<\/p>\n<\/section>\n

\n

\u8ad6\u6587<\/h4>\n
    \n
  • Koitabashi N<\/strong>, Kass DA.
    \nReverse remodeling in heart failure-mechanisms and therapeutic opportunities. Nat Rev Cardiol.<\/strong> 2012; 9: 147-157.<\/li>\n
  • Koitabashi N<\/strong>, Danner T, Zaiman AL, Pinto YM, Rowell J, Mankowski J, Zhang D, Nakamura T, Takimoto E, Kass DA.
    \nPivotal role of cardiomyocyte TGF-b signaling in the murine pathological response to sustained pressure overload. J Clin Invest<\/strong> 2011; 121: 2301-12<\/li>\n
  • Watanabe A, Arai M, Koitabashi N<\/strong>, Niwano K, Ohyama Y, Yamada Y, Kato N, Kurabayashi M.
    \nMitochondrial Transcription Factors, TFAM and TFB2M, Regulate Serca2 Gene Transcription. Cardiovasc Res<\/strong>. 2011; 90: 57-67.<\/li>\n
  • Koitabashi N<\/strong>, Aiba T, Hesketh GG, Rowell J, Zhang M, Takimoto E, Tomaselli, GF, Kass DA
    \nCyclic GMP\/PKG-dependent Inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation, Novel mechanisms of cardiac stress modulation by PDE5 inhibition. J Mol Cell Cardiol<\/strong>. 2010; 48: 713-24<\/li>\n
  • Koitabashi N<\/strong>, Bedja D, Zaiman AL, Pinto YM, Zhang M, Gabrielson KL, Takimoto E, Kass DA
    \nAvoidance of transient cardiomyopathy in cardiomyocyte-targeted tamoxifen-induced MerCreMer gene deletion models. Circ Res.<\/strong> 2009: 105: 12-5<\/li>\n
  • Niwano K, Arai M, Koitabashi N<\/strong>, Watanabe A, Ikeda Y, Miyoshi H, Kurabayashi M
    \nLentiviral vector-mediated SERCA2 gene transfer protects against heart failure and left ventricular remodeling after myocardial infarction in rats. Mol Ther<\/strong> 2008; 16: 1026-32<\/li>\n
  • Koitabashi N<\/strong>, Arai M, Kogure S, Niwano K, Watanabe A, Aoki Y, Maeno T, Nishida T, Kubota S, Takigawa M, Kurabayashi M
    \nIncreased connective tissue growth factor relative to brain natriuretic peptide as a determinant of myocardial fibrosis. Hypertension.<\/strong> 2007; 49: 1120-7<\/li>\n<\/ul>\n<\/section>\n
    \n

    \u5b66\u4f1a\u767a\u8868<\/h4>\n
      \n
    • American Heart Association, Scientific Sessions 2016,\u30002016.11.12-16\uff08New Orleans\uff09
      \nFurukawa N,Koitabashi N,Sunaga H,Obokata M,Yogi Umbarawan\u3001Yamaguchi A,Mass\u3000Rizky AA Syamsunaruno,Matsui H,Yokoyama T,Kurabayashi M.
      \nVildagliptin Attenuates Cardiac Hypertrophy and Improves Ventricular Efficiency through FGF21 Expression in Pressure-oberloaded Mouse Heart<\/li>\n
    • \u7b2c80\u56de\u65e5\u672c\u5faa\u74b0\u5668\u5b66\u4f1a\u5b66\u8853\u96c6\u4f1a\u30002016.3.18\uff5e20\uff08\u4ed9\u53f0\uff09
      \nKoitabashi N,Seki M\u3001Furukawa N\u3001Sunaga H\u3001Yokoyama T\u3001Kurabayashi M
      \nThe Role of Periostin Expressing Cells in Pathogenesis of Pulmonary Arterial Hypertension<\/li>\n
    • \u4ed6\u591a\u6570<\/li>\n<\/ul>\n<\/section>\n","protected":false},"excerpt":{"rendered":"

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