{"id":94,"date":"2020-05-26T17:52:00","date_gmt":"2020-05-26T08:52:00","guid":{"rendered":"https:\/\/gucvmed.med.gunma-u.ac.jp\/0_web\/?page_id=94"},"modified":"2020-05-28T17:34:58","modified_gmt":"2020-05-28T08:34:58","slug":"%e7%a3%af%e3%82%b0%e3%83%ab%e3%83%bc%e3%83%97","status":"publish","type":"page","link":"https:\/\/gucvmed.med.gunma-u.ac.jp\/?page_id=94","title":{"rendered":"\u78ef\u30b0\u30eb\u30fc\u30d7"},"content":{"rendered":"<section>\n<p>&emsp;\u79c1\u305f\u3061\u306f\u300110\u5e74\u6765\u3001\u5fc3\u81d3\u3068\u5168\u8eab\u306e\u8102\u80aa\u9178\u4ee3\u8b1d\u30fb\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u91cd\u306d\u3001in vivo\u4ee3\u8b1d\u3092\u591a\u89d2\u7684\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3001\u591a\u304f\u306e\u539f\u8457\u8ad6\u6587\u3092\u767a\u8868\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u5185\u5bb9\u30924\u3064\u306b\u5206\u3051\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002<\/p>\n<h4>1. FABP4\/5\u3092\u4ecb\u3059\u308b\u7d4c\u5185\u76ae\u7684\u8102\u80aa\u9178\u8f38\u9001<\/h4>\n<p>&emsp;\u8102\u80aa\u9178\u4ee3\u8b1d\u306b\u304a\u3051\u308b\u6bdb\u7d30\u8840\u7ba1\u306e\u5f79\u5272\u306f\u3001\u3053\u308c\u307e\u3067\u307b\u3068\u3093\u3069\u8003\u616e\u3055\u308c\u3066\u3044\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u5fc3\u81d3\u30fb\u9aa8\u683c\u7b4b\u306a\u3069\u306b\u307f\u3089\u308c\u308b\u7b4b\u578b\u6bdb\u7d30\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306f\u9023\u7d9a\u578b\u6bdb\u7d30\u8840\u7ba1\u306b\u5c5e\u3057\u3001\u5faa\u74b0\u8840\u6db2\u3068\u5b9f\u8cea\u7d44\u7e54\u9593\u8cea\u3092\u9694\u3066\u7269\u8cea\u4ea4\u63db\u306e\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30a4\u30b9(\u5883\u754c\u9762)\u3068\u3057\u3066\u6a5f\u80fd\u3057\u307e\u3059\u3002fatty acid binding protein\uff08FABP1-9\uff09\u306f\u8102\u80aa\u9178\u306e\u7d50\u5408\u30bf\u30f3\u30d1\u30af\u3067\u3001\u4e3b\u306b\u7d30\u80de\u5185\u3067\u306e\u8102\u80aa\u9178\u306e\u8caf\u8535\u3068\u8f38\u9001\u306b\u95a2\u4e0e\u3059\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001FABP4\u3068FABP5\u304c\u3053\u308c\u307e\u3067\u767a\u73fe\u304c\u77e5\u3089\u308c\u3066\u3044\u305f\u8102\u80aa\u7d30\u80de\u30fb\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u4ee5\u5916\u306b\u3001\u5fc3\u81d3\u306e\u6bdb\u7d30\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u8c4a\u5bcc\u306b\u767a\u73fe\u3057\u3001\u3053\u308c\u307e\u3067\u77e5\u3089\u308c\u3066\u3044\u306a\u3044\u65b0\u305f\u306a\u6a5f\u80fd\u3092\u6709\u3059\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002FABP4\/5 double KO(DKO)\u30de\u30a6\u30b9\u306e\u5fc3\u81d3\u3067\u306f125I-BMIPP\uff08\u8102\u80aa\u9178\u30a2\u30ca\u30ed\u30b0\uff09\u306e\u53d6\u308a\u8fbc\u307f\u306f\u91ce\u751f\u578b\u306e70\uff05\u306b\u6e1b\u5c11\u3057\u3001\u76f8\u5bfe\u3057\u306618F-FDG\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u30a2\u30ca\u30ed\u30b0\uff09\u53d6\u308a\u8fbc\u307f\u304c\u91ce\u751f\u578b\u306e\u7d0420\u500d\u4e0a\u6607\u3057\u307e\u3057\u305f\uff08\u4e0b\u56f3\uff09\u3002\u3064\u307e\u308a\u3001\u53d7\u52d5\u7684\u62e1\u6563\u3067\u306f\u306a\u3044\u6bdb\u7d30\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306eFABP4\/5\u3092\u4ecb\u3059\u308b\u8f38\u9001\u306b\u3088\u308a\u3001\u904a\u96e2\u8102\u80aa\u9178\u306f\u8840\u4e2d\u304b\u3089\u5fc3\u7b4b\u9593\u8cea\u3078\u52b9\u7387\u3088\u304f\u904b\u642c\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\uff08\u7d4c\u5185\u76ae\u7684\u8102\u80aa\u9178\u8f38\u9001\u3001\u4e0b\u56f3\uff09\u3002\u8102\u80aa\u9178\u8f38\u9001\u304c\u969c\u5bb3\u3055\u308c\u308bFABP4\/5DKO\u30de\u30a6\u30b9\u306e\u5fc3\u81d3\u3067\u306f\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u3092\u88dc\u3046\u305f\u3081\u306b\u4ee3\u511f\u7684\u306b\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u304c\u8457\u3057\u304f\u4ea2\u9032\u3059\u308b\u3053\u3068\u3082\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u3053\u306e\u4e8c\u6b21\u7684\u306a\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u4ea2\u9032\u306f\u30a4\u30f3\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u7684\u3067\u3042\u308a\u3001\u30a2\u30ed\u30b9\u30c6\u30ea\u30c3\u30af\u8abf\u6574\u3084\u8ee2\u5199\u5f8c\u8abf\u6574\u306b\u3088\u308a\u7cd6\u53d6\u308a\u8fbc\u307f\u4ea2\u9032\u30fb\u89e3\u7cd6\u7cfb\u4ea2\u9032\u304c\u751f\u3058\u308b\u3053\u3068\u306b\u3088\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p class=\"cc\"><img decoding=\"async\" src=\"https:\/\/gucvmed.med.gunma-u.ac.jp\/0_web\/wp-content\/uploads\/2020\/05\/basis02.png\" alt=\"\"><\/p>\n<p class=\"mini\">Iso T, Kurabayashi M, et al. Capillary Endothelial Fatty Acid Binding Proteins 4 and 5 Play a Critical Role in Fatty Acid Uptake in Heart and Skeletal Muscle.<br \/>\n\t\t\t\t\tArterioscler Thromb Vasc Biol. 2013. (corresponding author)<\/p>\n<p class=\"mini\">\nGoto K, Iso T (equal contributor), Kurabayashi M, et al. PPARgamma in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long-term Fasting.<br \/>\nJ Am Heart Assoc. 2013. (corresponding author)\n<\/p>\n<\/section>\n<section>\n<h4>2. \u8102\u80aa\u9178\u5229\u7528\u969c\u5bb3\u6642\u306e\u5168\u8eab\u306e\u4ee3\u8b1d\u5fdc\u7b54<\/h4>\n<p>&emsp;FABP4\/5\u306f\u9aa8\u683c\u7b4b\u306e\u9023\u7d9a\u578b\u6bdb\u7d30\u8840\u7ba1\u5185\u76ae\u7d30\u80de\u306b\u3082\u9ad8\u767a\u73fe\u3057\u307e\u3059\u3002\u8d64\u7b4b\u306e\u4e3b\u8981\u306a\u30a8\u30cd\u30eb\u30ae\u30fc\u57fa\u8cea\u306f\u8102\u80aa\u9178\u3067\u3042\u308a\u3001FABP4\/5 DKO\u30de\u30a6\u30b9\u3067\u306f\u3001\u8d64\u7b4b\u3067\u3082\u8102\u80aa\u9178\u5229\u7528\u304c\u4f4e\u4e0b\u3057\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u304c\u4ea2\u9032\u3057\u307e\u3059\u3002\u305d\u3053\u3067\u3001\u8102\u80aa\u9178\u5229\u7528\u306e\u4f9d\u5b58\u5ea6\u304c\u5897\u52a0\u3059\u308b\u7d76\u98df\u72b6\u614b\u3067\u306eDKO\u30de\u30a6\u30b9\u306e\u4ee3\u8b1d\u5fdc\u7b54\u3092\u89b3\u5bdf\u3057\u307e\u3057\u305f\u3002\u3059\u308b\u3068\u3001\u4f4e\u8840\u7cd6\u30fb\u9ad8\u904a\u96e2\u8102\u80aa\u9178\u30fb\u8457\u660e\u306a\u8102\u80aa\u809d\u30fb\u9ad8\u30b1\u30c8\u30f3\u4f53\u8840\u75c7\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306f\u3001\u9577\u671f\u7d76\u98df\u306b\u3088\u308a\u3001\uff081\uff09\u5fc3\u81d3\u30fb\u8d64\u7b4b\u3067\u8102\u80aa\u9178\u5229\u7528\u304c\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u904a\u96e2\u8102\u80aa\u9178\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3001\uff082\uff09\u4ee3\u511f\u7684\u306b\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u304c\u4ea2\u9032\u3059\u308b\u305f\u3081\u30a4\u30f3\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u7684\u306b\u8840\u7cd6\u304c\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u3001(3) \u5fc3\u7b4b\u30fb\u8d64\u7b4b\u3067\u5229\u7528\u3055\u308c\u306a\u3044\u8102\u80aa\u9178\u304c\u809d\u81d3\u306b\u96c6\u7a4d\u3059\u308b\u3053\u3068\u3001\uff084\uff09\u809d\u81d3\u3067\u306e\u8102\u80aa\u9178\u9178\u5316\u306f\u969c\u5bb3\u3055\u308c\u306a\u3044\u305f\u3081\u30b1\u30c8\u30f3\u4f53\u7523\u751f\u304c\u4ea2\u9032\u3059\u308b\u3053\u3068\u3001\u306b\u8d77\u56e0\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u7d76\u98df\u5f8c\u306b\u5bd2\u51b7\u74b0\u5883\u4e0b\uff084\u2103\uff09\u306b\u66b4\u9732\u3059\u308b\u3068\u6025\u901f\u306a\u4f4e\u4f53\u6e29\u3092\u5448\u3057\u3001\u307e\u305f\u3001\u7d76\u98df\u5f8c\u306b\u30c8\u30ec\u30c3\u30c9\u30df\u30eb\u8ca0\u8377\u3092\u884c\u3046\u3068\u8457\u660e\u306a\u6301\u4e45\u904b\u52d5\u80fd\u306e\u4f4e\u4e0b\u3092\u5448\u3057\u307e\u3057\u305f\u3002\u3053\u308c\u3089\u306e\u73fe\u8c61\u306f\u3001\u71b1\u7523\u751f\u306e\u305f\u3081\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\uff08\u8910\u8272\u8102\u80aa\u7d44\u7e54\u306e\u4e2d\u6027\u8102\u80aa\u3068\u9aa8\u683c\u7b4b\u306e\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\uff09\u3084\u6301\u4e45\u904b\u52d5\u306e\u305f\u3081\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u6e90\uff08\u809d\u81d3\u3068\u9aa8\u683c\u7b4b\u306e\u30b0\u30ea\u30b3\u30fc\u30b2\u30f3\uff09\u304c\u7d76\u98df\u306b\u3088\u308a\u6025\u901f\u306b\u67af\u6e07\u3057\u3001\u8840\u4e2d\u304b\u3089\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u57fa\u8cea\u306e\u88dc\u5145\uff08\u30b0\u30eb\u30b3\u30fc\u30b9\u3001\u8102\u80aa\u9178\uff09\u3082\u4f4e\u4e0b\u3059\u308b\u305f\u3081\u3068\u8003\u3048\u3089\u308c\u305f\u3002\u3053\u308c\u3089\u7d76\u98df\u6642\u306e\u4f4e\u4f53\u6e29\u3068\u904b\u52d5\u8010\u5bb9\u80fd\u306e\u4f4e\u4e0b\u306f\u3001CD36KO\u30de\u30a6\u30b9\u3067\u3082\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u5fc3\u81d3\u30fb\u9aa8\u683c\u7b4b\u3067\u8102\u80aa\u9178\u304c\u5229\u7528\u3067\u304d\u306a\u3044\u3068\u3001\u7d76\u98df\u6642\u306e\u30a8\u30cd\u30eb\u30ae\u30fc\u30db\u30e1\u30aa\u30b9\u30bf\u30b7\u30b9\u304c\u5bb9\u6613\u306b\u7834\u7dbb\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002\u3064\u307e\u308a\u3001\u9577\u671f\u306e\u98e2\u9913\u3084\u4f4e\u6e29\u306a\u3069\u3001\u60f3\u5b9a\u3055\u308c\u3046\u308b\u53b3\u3057\u3044\u81ea\u7136\u74b0\u5883\u306b\u5bfe\u3057\u3066\u975e\u8010\u6027\u306b\u306a\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p class=\"cc\"><img decoding=\"async\" src=\"https:\/\/gucvmed.med.gunma-u.ac.jp\/0_web\/wp-content\/uploads\/2020\/05\/basis03.png\" alt=\"\"><\/p>\n<p class=\"mini\">Iso T, Haruyama H, Kurabayashi M, et al. Exercise endurance capacity is markedly reduced due to impaired energy homeostasis during prolonged fasting inFABP4\/5 deficient mice. <br \/>\nBMC Physiol. 2019. (corresponding author)<\/p>\n<p class=\"mini\">\nIso T, Haruyama H, Kurabayashi M, et al. CD36 is indispensable for nutrient homeostasis and endurance exercise capacity during prolonged fasting. <br \/>\nPhysiol Rep. 2018. (corresponding author)\n<\/p>\n<p class=\"mini\">\nPutri M, Syamsunarno MRAA, Iso T, Kurabayashi M, et al. CD36 is indispensable for thermogenesis under conditions of fasting and cold stress. <br \/>\nBiochem Biophys Res Commun. 2015. (corresponding author)\n<\/p>\n<p class=\"mini\">\nSyamsunarno MRAA, Iso T, Kurabayashi M, et al. Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. <br \/>\nPLoS One. 2014. (corresponding author)\n<\/p>\n<p class=\"mini\">\nSyamsunarno MRAA, Iso T, Kurabayashi M, et al. A critical role of fatty acid binding protein 4 and 5 (FABP4\/5) in the systemic response to fasting. <br \/>\nPLoS One. 2013. (corresponding author)\n\t\t\t\t\t\t<\/p>\n<\/section>\n<section>\n<h4>3. \u8102\u80aa\u9178\u5229\u7528\u969c\u5bb3\u30de\u30a6\u30b9\u5fc3\u81d3\u306e\u75c5\u614b\u4e0b\u306e\u4ee3\u8b1d\u5fdc\u7b54<\/h4>\n<p>&emsp;FABP4\/5DKO\u30de\u30a6\u30b9\u3068CD36KO \u30de\u30a6\u30b9\u306f\u3001\u5fc3\u81d3\u306e\u8102\u80aa\u9178\u53d6\u308a\u8fbc\u307f\u304c\u91ce\u751f\u578b\uff08WT\uff09\u3068\u6bd4\u3079\u3066\u6e1b\u5c11\u3057\uff08DKO:\u7d043\u5272\u3001CD36KO:\u7d045\u5272\uff09\u3001\u4ee3\u511f\u7684\u304b\u3064\u30a4\u30f3\u30b9\u30ea\u30f3\u975e\u4f9d\u5b58\u7684\u306b\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u304c\u8457\u3057\u304f\u4ea2\u9032\u3057\u307e\u3059\uff08DKO:\u7d0420\u500d\u3001CD36KO:\u7d0435\u500d\uff09\uff08\u524d\u8ff0\u3001\u4e0a\u56f3\uff09\u3002\u8ca0\u8377\u306e\u306a\u3044\u72b6\u6cc1\u3067\u306f\u3001\u4e21\u30de\u30a6\u30b9\u306e\u5fc3\u6a5f\u80fd\u306fWT\u30de\u30a6\u30b9\u3068\u540c\u7b49\u3067\u3057\u305f\u304c\u3001\u5927\u52d5\u8108\u7e2e\u7a84\uff08\uff34\uff21\uff23\uff09\u306b\u3088\u308b\u5fc3\u81d3\u5727\u8ca0\u8377\u30e2\u30c7\u30eb\u3092\u4f5c\u6210\u3059\u308b\u3068\u3001DKO-TAC\u30de\u30a6\u30b9\u3068CD36KO-TAC\u30de\u30a6\u30b9\u3067\u306f\u3001TAC1\u9031\u9593\u5f8c\u3088\u308a\u3001\u5fc3\u6a5f\u80fd\u4f4e\u4e0b\u3092\u8a8d\u3081\u307e\u3057\u305f\u3002\u8907\u5408\u7684\u306ain vivo\u4ee3\u8b1d\u89e3\u6790\u306b\u3088\u308a\u3001TAC\u8ca0\u8377\u306b\u3088\u308aTCA\u56de\u8def\u306e\u4ee3\u8b1d\u7523\u7269\u306e\u7dcf\u548c\uff08\u30d7\u30fc\u30eb\u30b5\u30a4\u30ba\uff09\u3084ATP\u7523\u751f\u304c\u8457\u3057\u304f\u4f4e\u4e0b\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\uff08\u4e0b\u56f3\uff09\u3002\u307e\u305f\u3001KO\u30de\u30a6\u30b9\u306e\u5fc3\u81d3\u306b\u53d6\u308a\u8fbc\u307e\u308c\u305f\u30b0\u30eb\u30b3\u30fc\u30b9\u306e\u4ee3\u8b1d\u7523\u7269\u306fTCA\u56de\u8def\u306b\u5165\u308b\u3082\u306e\u306e\u3001\u305d\u306e\u4e00\u90e8\u306fde novo\u30a2\u30df\u30ce\u9178\u5408\u6210\u3084\u8102\u80aa\u9178\u5408\u6210\u306a\u3069\u5fc3\u80a5\u5927\u53cd\u5fdc\u306b\u5229\u7528\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\uff08\u4e0b\u56f3\uff09\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u30a8\u30cd\u30eb\u30ae\u30fc\u9700\u8981\u304c\u5897\u5927\u3059\u308b\u5727\u8ca0\u8377\u30b9\u30c8\u30ec\u30b9\u4e0b\u3067\u306f\u3001\u8102\u80aa\u9178\u53d6\u308a\u8fbc\u307f\u4f4e\u4e0b\u306b\u4f34\u3046\u4ee3\u511f\u7684\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u4ea2\u9032\u3060\u3051\u3067\u306f\u30a8\u30cd\u30eb\u30ae\u30fc\u4e0d\u8db3\u304c\u89e3\u6d88\u3055\u308c\u305a\u3001\u7dcf\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u4f9b\u7d66\u4e0d\u8db3\u304c\u9855\u5728\u5316\u3057\u3001\u5fc3\u6a5f\u80fd\u4f4e\u4e0b\u3092\u5448\u3059\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\uff08\u4e0b\u56f3\uff09\u3002\u30ea\u30dd\u30dd\u30ea\u30b5\u30c3\u30ab\u30e9\u30a4\u30c9\u6295\u4e0e\u306b\u3088\u308b\u6557\u8840\u75c7\u30e2\u30c7\u30eb\u306e\u5fc3\u81d3\u3067\u306f\u3001\u8102\u80aa\u9178\u4ee3\u8b1d\u306e\u307f\u306a\u3089\u305a\u3001\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u3082\u8457\u3057\u304f\u969c\u5bb3\u3055\u308c\u308b\u3053\u3068\u304c\u308f\u304b\u308a\u307e\u3057\u305f\u3002<\/p>\n<p class=\"cc\"><img decoding=\"async\" src=\"https:\/\/gucvmed.med.gunma-u.ac.jp\/0_web\/wp-content\/uploads\/2020\/05\/basis04.png\" alt=\"\"><\/p>\n<p class=\"mini\">\n\t\t\t\t\t\tUmbarawan Y, Syamsunarno MRAA, Kurabayashi M, Iso T, et al. Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure. <br \/>\nSci Rep. 2018. (corresponding author)\n<\/p>\n<p class=\"mini\">\nUmbarawan Y, Mas Rizky AA, Kurabayashi M, Iso T, et al. Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: Evidence from fatty acid binding protein-4 and -5 knockout mice. <br \/>\nCardiovasc Res. 2018. (corresponding author)\n<\/p>\n<p class=\"mini\">\nUmbarawan Y, Syamsunarno MRAA, Kurabayashi M, Iso T, et al. Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice. <br \/>\nMetabolism. 2017. (corresponding author)\n\t\t\t\t\t<\/p>\n<\/section>\n<section>\n<h4>4. \u8840\u4e2dFABP4\u4e0a\u6607\u306e\u75c5\u614b\u751f\u7406\u7684\u610f\u7fa9<\/h4>\n<p>&emsp;FABP4\u306f\u8102\u80aa\u7d30\u80de\u306b\u8c4a\u5bcc\u306b\u767a\u73fe\u3057\u3001\u8840\u4e2d\u306b\u653e\u51fa\u3055\u308c\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u8840\u4e2dFABP4\u306e\u4e0a\u6607\u306f\u3001\u80a5\u6e80\u30fb\uff12\u578b\u7cd6\u5c3f\u75c5\u30fb\u9ad8\u8840\u5727\u30fb\u8102\u80aa\u809d\u30fb\u52d5\u8108\u786c\u5316\u30fb\u6162\u6027\u814e\u81d3\u75c5\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u8840\u4e2dFABP4\u304c\u3001\u6025\u6027\u5fc3\u7b4b\u6897\u585e\u306e\u6025\u6027\u671f\u306b\u6700\u3082\u9ad8\u5024\u3068\u306a\u308a\u3001\u9662\u5916\u5fc3\u505c\u6b62\u306e\u75c7\u4f8b\u3067\u3001\u8457\u3057\u304f\u9ad8\u5024\u3092\u793a\u3059\u3053\u3068\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002\u5065\u5e38\u8005\u30dc\u30e9\u30f3\u30c6\u30a3\u30a2\u306e\u5fc3\u80ba\u904b\u52d5\u8ca0\u8377\u8a66\u9a13\u3067\u306f\u3001BMI\u304c\u5927\u304d\u3044\u307b\u3069\u3001\u904b\u52d5\u8ca0\u8377\u306e\u5f37\u5ea6\u304c\u5927\u304d\u3044\u307b\u3069\u3001\u8840\u4e2d\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u6fc3\u5ea6\u306e\u4e0a\u6607\u7387\u304c\u5927\u304d\u3044\u307b\u3069\u3001\u8840\u4e2dFABP4\u306e\u4e0a\u6607\u304c\u8a8d\u3081\u3089\u308c\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u8102\u80aa\u7d30\u80de\u306e\u84c4\u7a4d\uff08\u80a5\u6e80\uff09\u3068\u4ea4\u611f\u795e\u7d4c\u306e\u6d3b\u6027\u5316\u304c\u8840\u4e2dFABP4\u4e0a\u6607\u306e\u5927\u304d\u306a\u8981\u56e0\u3068\u306a\u308b\u3053\u3068\u304c\u63a8\u6e2c\u3055\u308c\u307e\u3057\u305f\u3002\u79c1\u305f\u3061\u306f\u3001\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3092\u7528\u3044\u3067\u814e\u6a5f\u80fd\u3068\u8840\u4e2dFABP4\u3068\u306e\u95a2\u9023\u3082\u8abf\u3079\u307e\u3057\u305f\u3002\u8840\u4e2dFABP4\u306f\u3001\u7cf8\u7403\u4f53\u3092\u901a\u904e\u3057\u814e\u81d3\u8fd1\u4f4d\u5c3f\u7d30\u7ba1\u4e0a\u76ae\u7d30\u80de\u306e\u5237\u5b50\u7e01\u306b\u767a\u73fe\u3059\u308b\u30e1\u30ac\u30ea\u30f3\u3092\u4ecb\u3057\u3066\u518d\u5438\u53ce\u3055\u308c\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u3055\u308c\u308b\u3053\u3068\u3092\u660e\u3089\u304b\u306b\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u814e\u6a5f\u80fd\u969c\u5bb3\u304c\u9032\u884c\u3059\u308b\u3068\u814e\u81d3\u306eFABP4\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u304c\u4f4e\u4e0b\u3057\u3001\u8840\u4e2dFABP4\u6fc3\u5ea6\u304c\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u793a\u3057\u307e\u3057\u305f\u3002\u4ee5\u4e0a\u3088\u308a\u3001\u8840\u4e2dFABP4\u6fc3\u5ea6\u306f\u3001\uff08\uff11\uff09\u8102\u80aa\u7d30\u80de\u306e\u84c4\u7a4d\u91cf\u3001\uff08\uff12\uff09\u4ea4\u611f\u795e\u7d4c\u306e\u6d3b\u6027\u5316\u3001\uff08\uff13\uff09\u814e\u81d3\u306eFABP4\u30af\u30ea\u30a2\u30e9\u30f3\u30b9\u306b\u3088\u308a\u5236\u5fa1\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p class=\"cc\"><img decoding=\"async\" src=\"https:\/\/gucvmed.med.gunma-u.ac.jp\/0_web\/wp-content\/uploads\/2020\/05\/basis05.png\" alt=\"\"><\/p>\n<p class=\"mini\">Obokata M, Iso T (equal contributor), Kurabayashi M et al. Early increase in serum fatty acid binding protein 4 levels in patients with acute myocardial infarction. <br \/>\nEur Heart J Acute Cardiovas Care. 2018.\n<\/p>\n<p class=\"mini\">\nIso T, Kurabayashi M, et al. Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise. <br \/>\nClin Biochem. 2017. (corresponding author)\n<\/p>\n<p class=\"mini\">\nShrestha S, Kurabayashi M, Iso T, et al. Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption. <br \/>\nSci Rep. 2018. (corresponding author)<\/p>\n<\/section>\n<section>\n<table class=\"result\">\n<thead>\n<tr>\n<td>[\u4e0a\u8a18\u5185\u5bb9\uff081, 2, 3\uff09\u306b\u95a2\u3059\u308b\u7dcf\u8aac\u3068\u8457\u66f8]<\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><span class=\"bold\">\uff08\u7dcf\u8aac\uff09<\/span><br \/>\n\u6708\u520a \u7d30\u80de 2014; 46 (7); 303-306, \u5185\u5206\u6ccc\u30fb\u7cd6\u5c3f\u75c5\u30fb\u4ee3\u8b1d\u5185\u79d1 2014; 39 (6); 449-454, Annual Review \u7cd6\u5c3f\u75c5\u30fb\u4ee3\u8b1d\u30fb\u5185\u5206\u6ccc 2015; 98-104, \u5faa\u74b0\u5668\u5185\u79d1 2017; 81(5); 476-482, \u5faa\u74b0\u5668\u5185\u79d1 2019; 85(3); 312-319, \u5fc3\u81d3\u30002020; 52 (2); 201-209.<br \/>\n<span class=\"bold\">\uff08\u8457\u66f8\uff09<\/span><br \/>\nIso T, Kurabayashi M. Fatty Acid Uptake by the Heart During Fasting. (Chapter 8) Effects of undernutrition: general aspects, organs and tissue systems. Handbook of Famine, Starvation, and Nutrient Deprivation (edited by Preedy and Patel). 2017: 1-20. Springer International Publishing. Chapter DOI: 10.1007\/978-3-319-40007-5_13-1.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>&emsp;\u79c1\u305f\u3061\u306f\u300110\u5e74\u6765\u3001\u5fc3\u81d3\u3068\u5168\u8eab\u306e\u8102\u80aa\u9178\u4ee3\u8b1d\u30fb\u30b0\u30eb\u30b3\u30fc\u30b9\u4ee3\u8b1d\u306b\u3064\u3044\u3066\u7814\u7a76\u3092\u91cd\u306d\u3001in vivo\u4ee3\u8b1d\u3092\u591a\u89d2\u7684\u306b\u8a55\u4fa1\u3059\u308b\u3053\u3068\u3067\u3001\u591a\u304f\u306e\u539f\u8457\u8ad6\u6587\u3092\u767a\u8868\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u307e\u3067\u306e\u7814\u7a76\u5185\u5bb9\u30924\u3064\u306b\u5206\u3051\u3066\u89e3\u8aac\u3057\u307e\u3059\u3002 1.  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